原标题：ALK是子宫炎症性肌纤维母细胞肿瘤特异性确诊标志物
- 来历：The American Journal of Surgical Pathology中文版
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摘要：炎症性肌纤维母细胞肿瘤（inflammatory myofibroblastictumor, IMT）是一种具有中度恶性潜能的肌纤维母细胞/纤维母细胞肿瘤，一般特征性地表现为ALK与多种伴侣基因发作基因交融，导致激酶抑制剂靶向的ALK信号通路激活。IMT可发作在女人生殖道，子宫（宫体和宫颈）是最常见的部位。近期研讨标明，发作于女人生殖道的IMT尚未被充分认识，主张至少要进行ALK免疫组织化学染色。本研讨的意图是评价ALK免疫组织化学染色对从子宫间叶和混合性上皮/间叶肿瘤中识别出IMT的特异性。咱们对14例经分子检测证明的子宫IMT和260例其他类型子宫单纯性间叶和混合性上皮/间叶肿瘤进行ALK免疫组织化学染色。肿瘤细胞呈细胞质和/或细胞膜上色的病例均被认为是ALK阳性。一切14例IMT经RNA测序均被证明具有ALK基因交融，且14例病例的ALK染色均出现核旁加剧的颗粒状细胞质上色形式。一切其他单纯性间叶肿瘤和混合性上皮/间叶肿瘤的ALK均为阴性（彻底缺少上色）。咱们的结果标明，ALK是具有ALK交融的子宫间叶肿瘤的一种高度特异的免疫组化符号物。在子宫间叶肿瘤（尤其是呈黏液样间质改动的平滑肌肿瘤）的确诊中，假如观察到ALK阳性，高度考虑确诊为IMT。
关键词：ALK, 子宫肉瘤，炎症性肌纤维母细胞肿瘤，基因交融
Am J Surg Pathol 2018;42:1353-1359）
美国外科病理学杂志中文版2019年第2期全文No.1
（杨 丽 翻译 张 静 审校）
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